Clock gene expression in hemodialysis patients

Clock gene expression in hemodialysis patients - CLEXID

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37872

Enrollment

Registered

2012-04-27

Start date

2012-07-10

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

circadian rhythm day-night rhythm

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Chronic hemodialysis patients: - Hospitalized, stable chronic hemodialysis patients - Written informed consent - Age 18-85 years - Good understanding of Dutch language;Control patients: - Hospitalized, stable patients - MDRD-GFR > 60 ml/min - Age and gender matched with hemodialysis patient - Written informed consent - Age 18-85 years - Good understanding of Dutch language

Exclusion criteria

Exclusion criteria: - Blindness - Fever - CRP > 20 mg/L - Diabetes - Serious co-morbidity that prevents participation in this study according to the investigators (e.g. neurological, psychiatric, angina, heart failure NYHA class IV)

Design outcomes

Primary

Measure	Time frame
Establish 24-hr peripheral clock gene and clock controlled output gene expression profiles in blood of chronic hemodialysis patients compared to control subjects to diagnose renal disease mediated circadian disruption.	—

Secondary

Measure	Time frame
1. Investigate the clock synchronization and phase-shifting potential of serum from chronic kidney disease patient and control groups. Renal patients are expected to have high levels of clock resetting compounds. 2. Determine the correlation between clock gene expression and a physiogical read-out (sleep).	—

Countries

Netherlands

Outcome results