Hypertension
Conditions
Interventions
All volunteers will use a high (6 gram/24 hours) and low (12 gram/24 hours)
sodium chloride diet (in random order
5 days on each diet, both periods
separated by at least 4 days). At the end of each period, 24 hour urine is
collected to assess sodium excretion. Volunteers will abstain from caffeine
containing b
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Signed informed consent. At least 18 years of age.
Exclusion criteria
Exclusion criteria: Use of any medication or recreational drugs (exept oral anticonception in female participants) Hypertension (defined as SBP > 140 mmHg and/or DBP > 90 mmHg as measured after at least 5 minutes in supine position by standard auscultatory measurements) Difference in blood pressure between the two arms of 10 mmHg or more (systolic) Alcohol consumption > 2 units/day Any cardiovascular abnormality as detected during routine history and physical examination. BMI > 25
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| response to coffee intake of blood pressure Dinamap and Nexfin) and cardiac output (Pulse contour method applied to continuous blood pressure signal that is measured at the finger using Nexfin) | — |
Secondary
| Measure | Time frame |
|---|---|
| sodium and creatinine excretion in urine; plasma caffeine concentration before and 2 hours after intake of 2 cups of coffee | — |
Countries
Netherlands
Outcome results
None listed