muscle metabolism disuse atrophy
Conditions
Interventions
Five days of one-legged knee immobilization in young individuals (YNG group),
and five days of one-legged knee immobilization in elderly individuals with
(OLD-PRO) or without (OLD-CON) twice daily d
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male Aged from 18-35 years and from 65-75 years 18.5
Exclusion criteria
Exclusion criteria: Smoking Performing regular resistance training in the previous 6 months Hypertension (according to WHO criteria) and/or cardiovascular disease Any back/leg/knee/shoulder complaints which may interfere with the use of crutches Systemic use of antibiotics within 3 weeks prior to the study visit Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin Type 2 diabetes mellitus Any family history of thrombosis All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis) Myocardial infarction within the last 3 years Use of anti-coagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quadriceps cross sectional area (CSA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Leg lean mass, type I and II muscle fiber CSA and satellite cell content, muscle strength, mRNA and protein expression of anabolic signaling proteins. | — |
Countries
Netherlands
Outcome results
None listed