demyelination disorder Multiple sclerosis
Conditions
Interventions
After patient selection, a skin punch biopsy ( diameter 4mm) will be performed
according to standard procedures under sterile conditions and after local
anesthesia at the department of Dermatology,
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 20 years or above. - Diagnosis of RRMS or PPMS according to the revised McDonald criteria independently confirmed by 2 neurologists . - Informed consent is obtained.
Exclusion criteria
Exclusion criteria: - Patients under 20 years of age. - Unclear diagnosis of stage/type of the disease - Recent (less than 4 weeks) treatment with high dose intravenous methylprednisolone - Ongoing treatment with immunomodulating drugs other than interferon-beta or copaxone - Extensive skin disorder precluding a biopsy from unaffected skin area - Known allergy for local anesthetics - Informed consent can, for whatever reason, not be obtained (f.i. the presence of neurological deficits that preclude a reliable verbal communication or lead to cognitive disability).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - IPS cells can be generated from skin fibroblasts of MS patients and differentiated into OPCs and functional oligodendrocytes - OPCs and oligodendrocytes derived from MS patients via IPS reprogramming show differences in expression profiles and in responses to stress in comparison to those of healthy controls. | — |
Countries
Netherlands
Outcome results
None listed