adiposity obesity
Conditions
Interventions
Subjects will receive meal replacements, replacing either all or part of the
daily meals, during the intervention period. The first group will consume a 500
kcal/d diet for 5 weeks while the second
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy volunteers aged 20-65 y, BMI 28-35 kg/m2, non-smokers
Exclusion criteria
Exclusion criteria: Subjects using prescription medication, or suffering from diseases or conditions that might influence the outcome of the study: this concerns diseases/medication that influence body weight regulation (malabsorption, untreated hypo/hyperthyroidism, eating disorders, systemic use of steroids, etc.) and obesity-related cardiovascular risk factors (heart disease, systolic and diastolic blood pressures > 160/100 mmHg, blood glucose > 6.1 mmol L-1, blood cholesterol > 7 mmol L-1, blood triglycerides > 3 mmol L-1), marked alcohol consumption > 21 alcoholic units week-1 (male), or >14 alcoholic units week-1 (female), planned major changes in physical activity during the study to an extent that might interfere with the study outcome, as judged by the investigator; blood donation within the past 2 months prior to the study; weight change of >3 kg within 2 months prior to the study; psychiatric disease (based on medical history only); pregnant or lactating women, or women planning to become pregnant within the next 12 months; surgically treated obesity; participation in other clinical studies within the last 3 months; drug abuse (based on clinical judgment); unable to give informed consent; unable to engage in a low-calorie diet; following a special diet (e.g. Atkins).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The association between the amount of weight regain after the weight loss period and changes in adipokines, parameters of adipocyte metabolism, in vivo adipose tissue metabolism, adipocyte extracellular matrix gene expression profiles, adipocyte stress protein expression and gene polymorphisms in selected genes. | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference in weight regain and associated parameters between rapid and slow weight loss regimens. | — |
Countries
Netherlands
Outcome results
None listed