GABA, excitability and plasticity in the human motor cortex, an explorative study

GABA, excitability and plasticity in the human motor cortex, an explorative study - GABA in the motor cortex

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37805

Enrollment

Registered

2012-02-03

Start date

2012-02-13

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

niet van toepassing not applicable

Interventions

During the intake session, participants will be screened and informed on the study in general and the TMS application in particular. During the following three experimental sessions, each participan

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy, right-handed partcipants (males and females). Age 18-35 years.

Exclusion criteria

Exclusion criteria: Contra-indications for TMS and fMRI: drug abuse, head trauma, neurological or psychiatric illness, pregnancy, heart disease, claustrophobia, cardiac pacemakers, metal objects in the body, medication pumps, tricyclic antidepressants, neuroleptics and a familiy history of neurological illness or epilepsy.

Design outcomes

Primary

Measure	Time frame
MEP and SICI amplitudes are measured using EMG, resting-state connectivity (RSC) is indexed by analyzing rs-fMRI and GABA concentration is determined using MR spectroscopy. The modulation of these measurements by rTMS will inform us on the mechanistic relationship between GABA, excitability and plasticity in the primary motor cortex.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)