Whole genome sequencing of children born after fertilization with ICSI using testicular sperm

Whole genome sequencing of children born after fertilization with ICSI using testicular sperm - Genome sequencing in TESE children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37802

Enrollment

Registered

2012-10-22

Start date

2013-01-15

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

observationele studie van nakomelingen van onvruchtbare mannen genetic anomalies

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Ten trios (10 children and parents) will be tested. The only inclusion criteria for this study is that children are born after fertilization with testicular sperm and ICSI from males (father) with a non obstructive azoospermia (poor spermatogenesis).

Exclusion criteria

Exclusion criteria: All other children and parents that do not meet the inclusion criteria. Fathers with a known genetic anomaly will be excluded from the study. Language barrier for understanding the reason for this study.

Design outcomes

Primary

Measure	Time frame
The number and type of de novo mutations found in the study group (TESE-ICSI children).	—

Countries

Netherlands

Outcome results