atherosclerosis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - patients scheduled for coronary angiography (CAG)in combination with fractional flow reserve (FFR)/ coronary flow reserve (CFR) measurements - 18 years or older - signed, written informed consent
Exclusion criteria
Exclusion criteria: - acute coronary syndrome - atrial fibrillation - previous coronary bypass graft surgery - previous myocardial infarction - impaired left ventricular (LV) function (ejection fraction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. to compare the diagnostic performance of coronary CTA with MRA to detect significant coronary stenoses (> 50% reduction in lumen diameter), in patients with a range of coronary calcium scores, using conventional angiography as a reference standard Coronary CTA: Significant stenoses (>50% reduction in diameter) Coronary MRA: Significant stenoses (>50% reduction in diameter) CAG: Significant stenoses (>50% reduction in diameter) 2. to assess the diagnostic performance of coronary MRA in combination with perfusion and late enhancement MR imaging to detect hemodynamically significant stenoses, using FFR and CFR as a reference standard Coronary MRA, perfusion MR and late enhancement MR imaging: visually decreased or absent perfusion. hemodynamically significant stenoses: (1) diameter stenoses >70%, (2) 30-70% stenoses if the FFR is | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed