Parkinsonism Parkinson's Disease
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - The probands (index cases) must have a diagnosis of idiopathic Parkinson*s disease according to the established clinical criteria (familial or sporadic disease). - The relatives of the probands are first-, second-, or third-degrees relatives of the probands; they might or might not have Parkinson*s disease. - The unrelated controls, as well as their first degree relatives, must be free from clinical signs of Parkinson*s disease and dementia. - All subjects (probands, relatives, controls) must be 18 years of age at recruitment. - All subjects (probands, relatives, controls) might be male or female. - All subjects (probands, relatives, controls) must have signed the informed consent (before entry into study). In case of a legally incapacited subject, for instance due to cognitive impairment, the legal representative will be approached to obtain informed consent.
Exclusion criteria
Exclusion criteria: - Subjects who are unable to speak and be interviewed in Dutch or English (to ensure validity of the interviews). - Patients with secondary forms of parkinsonism (such as drug-induced, toxic, vascular, tumour)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Genetics variants causing or predisposing to Parkinson*s disease. - Characterisation of the clinical phenotype associated to specific genetic variants. | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of known mutations in the subjects. | — |
Countries
Netherlands
Outcome results
None listed