Wasting Weight loss
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Resectable non-small cell lung cancer (NSCLC) Age 40-70 years Gender: male and female Caucasians Non-obese persons, i.e. Body Mass Index (BMI)
Exclusion criteria
Exclusion criteria: Primary • Body Mass Index > 30 kg/m2 • Medically treated Diabetes mellitus (oral anti-diabetics, insulin) • Severe COPD and/or heart failure • Patients with severe clotting disorder • Patients with a second malignancy, either active or in previous medical history • Thyroid disorders • Psychological unstable persons presumed unfit to perform the measurements, including claustrophobia • Patients with shortness of breath in rest • Persons unable to lie or sit still for1-2 hours • Pregnant subjects • Subjects that received high doses of radiotherapeutic radiation of the neck and/or upper chest in their medical history • Persons that received cervical of thoracic sympathectomy or have a nerve dysfunction which is likely to influence sympathetic nerves • The use of the medication that influences the sympathetic nerve system: ß-blockers, a-blockers, central anti-hypertensives, certain anti-depression drugs (MAO inhibitors, tricyclic anti-depressives) reserpine, cocaïne, calciumblockers, labetalol, certain tranquillizers (fenothiazines) • Exclusion criteria for core temperature measurement: -In any patient whose body weight is less than 40 kg -In the presence of any known or suspected obstructive disease of the gastrointestinal tract -In any patient exhibiting or having a history of disorders or impairment of the gag reflex -In any patient with previous gastrointestinal surgery -In any patient having structural and/or functional disorders of the esophagus -In any patient who might undergo Nuclear Magnetic Resonance (NMR) or MRI scanning during the period that the CorTemp* Disposable Temperature Sensor is within the body. -In any patient with hypo motility disorders of the gastrointestinal tract -In any patient having a cardiac pacemaker or other implanted electro medical device.;Secondary • Unsuccesful complete macro- and microscopic resection of the lung tumor • Presence of tumor recurrence on the second PET-CT scan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BAT volume and intensity in kBq/SUV in the presence (before operation) compared to absense (after operation) of lung cancer, as determined by 18 F-FDG PET-CT scanning. | — |
Secondary
| Measure | Time frame |
|---|---|
| Second primary endpoint are the effects on energy expenditure, body core temperature, skin surface temperature, body composition and serum leverls of CRP and selected hormones that influence BAT activity | — |
Countries
Netherlands
Outcome results
None listed