Residual effects of Cushing*s syndrome after long term remission: Impact on adipose tissue, insulin resistance, exercise intolerance and increased risk of cardiovascular disease.

Residual effects of Cushing*s syndrome after long term remission: Impact on adipose tissue, insulin resistance, exercise intolerance and increased risk of cardiovascular disease. - Residual effects of Cushing*s syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37749

Enrollment

Registered

2012-07-11

Start date

2012-09-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypercortisolism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Subjects should be over 18 years old with the ability to read and comprehend the Dutch language - Patients should be successfully cured for at least five years. Current remission should be confirmed by a recent 1mg dexamethasone suppression test

Exclusion criteria

Exclusion criteria: - GH deficiency (This should be ruled out by an insulin tolerance test or an arginine/GHRH test) unless GH is properly supplemented (IGF-1 * 2) - Serious co-morbidity (i.e. terminal malignancy, serious psychiatric pathology) - Pregnancy - Known diabetes mellitus - Use of medication interfering with the cardiovascular system (ACE inhibitors, calcium antagonists, angiotensin II receptor antagonists) or adiponectins (thiazolidinediones) - Severe cardiopulmonary disease as stated in the 2001 American heart association and 2002 American college of cardiology/American heart association guidelines - Orthopedic and/or neurological diseases that impair exercise

Design outcomes

Primary

Measure	Time frame
- Physical fitness measured with an incremental cycling exercise test to exhaustion (VO2max-test). - Brachial %FMD levels as a marker of conduit artery endothelial function, NO-mediated endothelium-(in)dependent vasodilation of the forearm resistance arteries. - Mitochondrial and capillary density, eNOS levels and eNOS phosphorylation, NADPH oxidase activation, total JNK activity levels and expression of IKK* in skeletal muscle cells. - Amount of cytokines, adipokines and their mRNA and macrophage infiltration in subcutaneous fat tissue.	—

Measure

Time frame

- Physical fitness measured with an incremental cycling exercise test to exhaustion (VO2max-test). - Brachial %FMD levels as a marker of conduit artery endothelial function, NO-mediated endothelium-(in)dependent vasodilation of the forearm resistance arteries. - Mitochondrial and capillary density, eNOS levels and eNOS phosphorylation, NADPH oxidase activation, total JNK activity levels and expression of IKK* in skeletal muscle cells. - Amount of cytokines, adipokines and their mRNA and macrophage infiltration in subcutaneous fat tissue.

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Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results