mental processes Psychological disstress
Conditions
Interventions
None listed
Sponsors
Atrium Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Parkinson's Disease according to the UKPDS Brain Bank Criteria as diagnosed by a neurologist. - Stabel dosage of "anti-parkinsonian" medication at onset of the study
Exclusion criteria
Exclusion criteria: - Surgical treatment for PD, such as deep brain stimulation. - Suspected dementia at the onset of the study. - Presence of co-morbid neurological disorder (e.g. CVA) or infection (e.g. meningitis) within last 5 years other than PD that influences cognitive functioning. - Medication (e.g. corticosteroid) that influences daily cortisol levels. - Presence of posttraumatic stress disorder and/or psychotic disorders which influences cognitive functioning. - Depression according to the Beck Depression Inventory (BDI), cut-off score 15 for PD patients and cut-off score 10 for healthy controls.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Different parameters for stress will be taken into account (cortisol levels, scores on a perceived stress questionnaire). Furthermore, performance on cognitive tasks will be assessed in the PD group and control group. Both groups will be compared with each other. There will be assessed whether: - stress (chronic and acute) influences cognitive functioning in PD - chronic stress is associated with an accelerated cognitive decline in PD | — |
Secondary
| Measure | Time frame |
|---|---|
| Different parameters for stress will be taken into account (induced stress, vulnerability to perceive stress). Furthermore, performance on cognitive tasks as well as medical decision making tasks will be assessed in the PD group and control group. Both groups will be compared with each other. There will be assessed whether: - induced stress influences cognitive functioning in PD - vulnerability to perceive stress moderates the influence of (chronic and acute) stress on cognitive functioning in PD. - cognitive functioning mediates the influence of stress on medical decision making in PD. | — |
Countries
Netherlands
Outcome results
None listed