Hypercholesterolemia
Conditions
Interventions
During each test period, the volunteers will use a plant sterol/stanol poor
diet for 1 week followed by the consumption of the investigational products
(margarines with or without added plant stanol
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: aged between 18 and 60 years Body Mass Index (BMI) between 20-30 kg/m2 mean serum total cholesterol
Exclusion criteria
Exclusion criteria: unstable body weight (weight gain or loss > 3 kg in the past two months) - active cardiovascular diseases like congestive heart failure or recent (21 units per week) - not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in sterol or stanol esters - use of an investigational product within another biomedical study within the previous month - pregnant or breast-feeding women - not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study - current smoker - anemia. with a Hb-level below 7.5 mmol/L for men and below 7.0 mmol/L for women, as indicated by the blood bank of Maastricht - gastrointestinal diseases - not willing to stop the consumption of probiotica and antibiotica during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of the intestinal mucosal gene expression profiles. | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of changes in microbiota composition. Serum/plasma concentrations of plant sterols/stanols, lipids, lipoproteins, free fatty acids, glucose, insuline and markers of endothelial dysfunction. Analysis of the expression of nutrient sensing receptors (T1R2, T1R3,...) | — |
Countries
Netherlands
Outcome results
None listed