Is the lower incidence of intradialytic hypotension during Hemocontrol dialysis in comparison with standard hemodialysis attributable to enhanced to higher plasma vasopressin levels or to enhanced sympathetic activity and/or to less nitric oxide production?

Is the lower incidence of intradialytic hypotension during Hemocontrol dialysis in comparison with standard hemodialysis attributable to enhanced to higher plasma vasopressin levels or to enhanced sympathetic activity and/or to less nitric oxide production? - Vasopressin, sympathetic activity, nitric oxide, dialysis hypotension

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37739

Enrollment

Registered

2012-07-25

Start date

2012-09-17

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vasopressine, sympathicusactiviteit, stikstofoxideproductie en dialyse hypotensie Dialysis hypotension

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Hypotension-prone dialysis patients including patients who have stable hemodialysis session on Hemocontrol but previously had dialysis hypotension on standard hemodialysis

Exclusion criteria

Exclusion criteria: Patients on hemodialysis duration 4 hours

Design outcomes

Primary

Measure	Time frame
Primary outcome Plasma vasopressin levels	—

Secondary

Measure	Time frame
Secondary outcomes Sympathetic activity (primarily defined as the low frequency band in measurements of heart rate variability, secondarily defined as plasma noradrenalin levels) and nitric oxide metabolites as a parameter of endogenous nitric oxide production of vascular endothelial cells. In addition, plasma sodium levels, plasma osmolality, baroreflex sensitivity, peripheral vascular resistance and the course of the relative blood volume, blood pressure and heart rate.	—

Measure

Time frame

Secondary outcomes Sympathetic activity (primarily defined as the low frequency band in measurements of heart rate variability, secondarily defined as plasma noradrenalin levels) and nitric oxide metabolites as a parameter of endogenous nitric oxide production of vascular endothelial cells. In addition, plasma sodium levels, plasma osmolality, baroreflex sensitivity, peripheral vascular resistance and the course of the relative blood volume, blood pressure and heart rate.

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Countries

Netherlands

Outcome results