Neurobiological mechanisms of depression in Parkinson's disease

Neurobiological mechanisms of depression in Parkinson's disease - Depression in Parkinson's disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37738

Enrollment

Registered

2012-04-19

Start date

2012-11-05

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Idiopatic Parkinson's disease Age between 30 and 70 Hoehn & Yahr stage 1 - 2.5 (mild to moderate disease) ADL independent

Exclusion criteria

Exclusion criteria: Severe depression according to the DSM IV Dementia Use of antidepressants or other psycho-active drugs Severe comorbidity (including neurologic and psychiatric comorbidity) Contra-indications for MRI

Design outcomes

Primary

Measure	Time frame
We will measure error rates and brain activity using fMRI while participants perform a feedback-based learning task on a computer. Sensitivity to reward and punishment will be also tested outside the context of learning (after scanning) using two additional behavioral tasks. Furthermore, we will investigate the association between depressive symptoms, sensitivity to reward and genetic polymorphisms in dopaminergic genes, for instance DAT1.	—

Measure

Time frame

We will measure error rates and brain activity using fMRI while participants perform a feedback-based learning task on a computer. Sensitivity to reward and punishment will be also tested outside the context of learning (after scanning) using two additional behavioral tasks. Furthermore, we will investigate the association between depressive symptoms, sensitivity to reward and genetic polymorphisms in dopaminergic genes, for instance DAT1.

—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results