Comprehensive detection of childhood cancer predisposing genes using exome sequencing: The next step towards personalized treatment and cancer prevention.

Comprehensive detection of childhood cancer predisposing genes using exome sequencing: The next step towards personalized treatment and cancer prevention. - Detection of childhood cancer predisposing genes using exome sequencing

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37736

Enrollment

180

Registered

2013-01-03

Start date

2013-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kanker op de kinderleeftijd childhood cancer pediatric tumors

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Individuals diagnosed with any form of childhood cancer and one of the following characteristics will be included: • Intellectual disability, • Congenital anomalies, • Adult type of cancer in a child • First or second degree relative with the same type of cancer. • Second primary malignancy as well as their parents

Exclusion criteria

Exclusion criteria: A known genetic defect in the family for a cancer unrelated condition, of which the child might be a carrier but about which the child/parents do not want to be informed.

Design outcomes

Primary

Measure	Time frame
Mutations in known and novel pediatric cancer predisposing genes.	—

Secondary

Measure	Time frame
The results of this exome sequencing project will likely result in novel clinical, molecular genetic, and functional studies in order to explore the impact on clinical practice and to investigate novel functional pathways in childhood cancer initiation and development.	—

Countries

Netherlands

Outcome results