nasal hypersenstivitiy vasomotor rhinitis
Conditions
Interventions
All groups will undergo a nasal provocation with dry cold air for 15 minutes.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male or female between 18-68 years of age inclusive capable of giving written informed consent
Exclusion criteria
Exclusion criteria: Use of nasal corticosteroids within 4 weeks before participation Nasal conditions likely to effect the outcome of the study, i.e. nasal malformations Use of intranasal medication to treat nasal symptoms Nasal or sinussurgery in the previous three months Use of antihistamines in the 48 hours before each visit Recent upper airway infection Serious or unstable co-morbidity A diagnosis of asthma Pregnant or lactating females Past medical history of nasal polyposis Smoking Inability to follow the instructions or completing all studyprocedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical outcomes (symptomscore and nasal flow): Symptomscore The patient will be asked 1 minute before and 1 minute after provocation to assess the degree of their nasal symptoms by completing a 100 mm Visual Analogue Scale (VAS) and a Rhinitis Symptom Score (RSS). An example of the 100 mm visual analogue scale is illustrated below: No symptoms Worst possible symptoms The patients will also be asked to complete a rhinitis symptom score (RSS) for the following symptoms: rhinorrhoea, nasal blockage, sneezing, itching in the nose and burning in the nose. Symptom score None (0) Mild (1) Severe (2) Rhinorrhea Blockage Sneezing Itching in nose Burning in nose Nasal Flow: Peak Nasal Inspiratory Flow Rate (PNIF): An "InCheck" peak nasal inspiratory flow meter is used to derive forced inspiratory peak flow through the nose. Three maximal inspiratory efforts will be made and the highest value recorded. PNIF will be measured one minute before and minute after provocation. | — |
Countries
Netherlands
Outcome results
None listed