coagulation hemostasis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient group: - >18 year - Signed informed consent - First liver transplantation with a full-size graft - Adequate graft function in past year follow-up Control group of healhty volunteers: - >18 year - Signed informed consent
Exclusion criteria
Exclusion criteria: Patient group: - Documented history of congenital coagulation disorder - Active infection - Active rejection - Disease recurrence - Graft failure - Use of anticoagulant medicine within a period prior to the blood draw that is shorter than the wash-out period of the specific drug (typically within 10 days of the blood draw). - Pregnancy Control groupof healthy volunteers: - Documented history of congenital coagulation disorder - History of vascular disease - History of hepatic disease - History of any systemic disease - Recent viral infection (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thrombin generation by Calibrated Automated Thrombinography | — |
Secondary
| Measure | Time frame |
|---|---|
| - Platelet activatability as evidenced by flow cytometry - Plasma levels of VWF and ADAMTS13 - Fibrinolytic potential as assessed by a plasma-based clot lysis assay | — |
Countries
Netherlands
Outcome results
None listed