Cerebrovascular accident stroke
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: a. Clinical first-ever minor ischemic stroke (with minor defined as National Institutes of Health Stroke Scale [NIHSS] score 20)
Exclusion criteria
Exclusion criteria: a. Not having enough understanding of the Dutch language b. Not being able to attend follow-up visits due to home address outside catchment area of UMCG c. Prior disability (modified Rankin Scale [mRS] > 1) d. Presence of one or more of the following in the 15 days prior to inclusion: chronic inflammatory diseases, severe hepatic or renal diseases, haematological diseases, cancer, infectious disease, anti-inflammatory or immune suppressing therapy e. Pre-existent neurological or psychiatric illnesses (as described in the patient*s medical file) f. No informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Prevalence of post-stroke fatigue at 3 months and 1 year after a minor stroke, defined as an FSS (Fatigue Severity Scale) score >= 4 in combination with a validated case definition for post-stroke fatigue (*Over the past month, there has been at least a 2-week period when patient has experienced fatigue, a lack of energy, or an increased need to rest every day or nearly every day. This fatigue has led to difficulty taking part in everyday activities*) - Characteristics of post-stroke fatigue as assessed by the MFI-20 (Multidimensional Fatigue Inventory) and a semistructured interview - Prevalence of cognitive disorders at 4 months after stroke, with cognitive disorders defined as a score = 2 cognitive subdomains AND/OR a score | — |
Secondary
| Measure | Time frame |
|---|---|
| - Correlations of anxiety and depression, coping, sleep disturbances, pro- and anti-inflammatory markers, stroke characteristics and cognitive dysfunction with fatigue - Correlations of quality of life, return to work and activity level with fatigue | — |
Countries
Netherlands
Outcome results
None listed