neurotransmitter systeem (serotonine) obsessive compulsive disorder
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) 20 subjects (male/ female) currently aged 23-45 years of age with (a history of) OCD and at least 4 months of treatment with an SSRI at or before 18 years of age, and medication free for at least one month. 2) 20 subjects (male/ female) currently aged 23-45 years of age with (a history of) OCD and at least 4 months of treatment with an SSRI at or after 23 years of age, and medication free for at least one month. 3) 20 subjects (male/ female) currently aged 23-45 years of age with (a history of) OCD and without any previous treatment with SSRIs or other antidepressants.
Exclusion criteria
Exclusion criteria: -IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) 5-HT system function with functional MRI before and after an i.v. challenge with citalopram (5-HT challenge phMRI) 2) microarchitecture of 5-HT projections, using diffusion tensor imaging (DTI) 3) functional connectivity between several brain areas, using rs-fMRI | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) cognitive function related to dopaminergic function using neuropsychologic tests and fMRI tasks (verbal memory, impulsivity, emotional processing) 2) confounding of genetic markers of the 5-HT system 3) cortisol sampling as indirect measure of 5-HT function | — |
Countries
Netherlands
Outcome results
None listed