The prevalence of brain white matter lesions after pregnancy and the relationship with neurocognitive functioning

The prevalence of brain white matter lesions after pregnancy and the relationship with neurocognitive functioning - Brain white matter lesions and neurocognitive function after pregnancy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37705

Enrollment

Registered

2012-01-23

Start date

2012-02-24

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognition Pregnancy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: One group of women who were never pregnant will be included in this study. Women will be recruited by means of an invitation which will be spread in local newspapers and on the internet. Women can reply to this invitation. From the repliers, 62 women will be matched for age and level of education with a healthy parous woman from a previous study.

Exclusion criteria

Exclusion criteria: - Any pregnancy of more than 12 weeks gestation or current pregnancy - Epilepsy or other neurologic disorder - Pregnancy - General MRI contraindications or claustrophobia - Known cerebrovascular disease - History of alcohol or substance abuse requiring therapy - Insufficient comprehension of Dutch language - Fertility treatment or diagnostic procedures

Design outcomes

Primary

Measure	Time frame
The main study parameter is the prevalence of white matter lesions assessed by MRI using a 3 Tesla MRI.	—

Secondary

Measure	Time frame
Secundary study parameters are: Scores on the questionnaires: cognitive failures questionnaire (CFQ), hospital anxiety and depression questionnaire (HADS), Utrechtse coping lijst (UCL). Scores on neurocognitive tests: - Nederlandse Leestest voor Volwassenen (NLV) - Wechsler Adult Intelligence Scale (WAIS) III letter-number sequencing and digit span, digit-symbol coding, symbol search - Corsi Block-Tapping Task - 15-Word Learning test - Location Learning test - Grooved Pegboard - Groningen Intelligence Test (GIT) II figure exploration - Delis-Kaplan Executive Function System (D-KEFS) Trail Making test, Tower test - STROOP Color Word test - Verbal Fluency test - Figure Fluency test - Amsterdam Short-Term Memory (ASTM) test	—

Measure

Time frame

Secundary study parameters are: Scores on the questionnaires: cognitive failures questionnaire (CFQ), hospital anxiety and depression questionnaire (HADS), Utrechtse coping lijst (UCL). Scores on neurocognitive tests: - Nederlandse Leestest voor Volwassenen (NLV) - Wechsler Adult Intelligence Scale (WAIS) III letter-number sequencing and digit span, digit-symbol coding, symbol search - Corsi Block-Tapping Task - 15-Word Learning test - Location Learning test - Grooved Pegboard - Groningen Intelligence Test (GIT) II figure exploration - Delis-Kaplan Executive Function System (D-KEFS) Trail Making test, Tower test - STROOP Color Word test - Verbal Fluency test - Figure Fluency test - Amsterdam Short-Term Memory (ASTM) test

—

Countries

Netherlands

Outcome results