The role of sleep in emotional memory processing and neurocognitive functioning in patients with posttraumatic stress disorder

The role of sleep in emotional memory processing and neurocognitive functioning in patients with posttraumatic stress disorder - Sleep and memory in PTSD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37626

Enrollment

Registered

2012-06-28

Start date

2012-07-26

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posttraumatic stress disorder posttraumatic stress syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for the PTSD group are: 1) Meeting diagnostic criteria for PTSD according to Clinician-Administered PTSD Scale (CAPS) with a total score of at least 50; 2) Age between 18 and 65; 3) Eligible for trauma-focused psychotherapy; 4) Written informed consent.;Inclusion criteria for the trauma-exposed control group are: 1) Having experienced at least one traumatic event as defined by DSM-IV in the absence of diagnostic criteria for PTSD according to CAPS and criteria for severe MDD according to MINI-PLUS clinical interview; 2) Age between 18 and 65; 3) Written informed consent.;Inclusion criteria for the non-trauma exposed control group are: 1) Having experienced no traumatic events as defined by DSM-IV and absence of diagnostic criteria for PTSD according to CAPS and criteria for severe MDD according to MINI-PLUS clinical interview; 2) Age between 18 and 65; 3) Written informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria for all groups are: 1) Acute suicidality; 2) Presence of a psychotic disorder, bipolar disorder, depression with psychotic features, or excessive substance related disorder over the past 3 months; 3) Prior history of neurological or sleep disorders, or an atypical sleep pattern with less than 6 hours sleep per night, or sleep time outside the window of 10 PM till 10 AM (for the PTSD group: neurological or sleep disorders prior to onset of PTSD).

Design outcomes

Primary

Measure	Time frame
The primary study parameters are memory for emotional and neutral film fragments, physiological signals during film fragments (ECG, respiratory effort, galvanic skin response), and emotional responses during the film fragments. Further main study parameters are neurocognitive functions (attention, planning, declarative memory).	—

Secondary

Measure	Time frame
Correlates of sleep architecture will also be investigated in stress hormones. For the patient group, predictive effects of sleep architecture and memory processes on response to treatment will be studied.	—

Countries

Netherlands

Outcome results