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Effects of sub chronic oral tryptophan administrations on stress-induced mood and eating behaviour in healthy female volunteers differing in the 5-HTTLPR genotype

Effects of sub chronic oral tryptophan administrations on stress-induced mood and eating behaviour in healthy female volunteers differing in the 5-HTTLPR genotype - 5-HTTLPR genotype, sub chronic TRP, stress and emotional eating

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON37605
Enrollment
120
Registered
2012-04-23
Start date
2012-03-26
Completion date
Unknown
Last updated
2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

emotional eating stress-induced eating

Interventions

Half of participants will be provided with TRP-rich drinks (100 ml containing 1.0g of TRP, three times a day), and half will be provided with placebo (PLC) drinks (100 ml, three times a day) for sev

Sponsors

Universiteit Maastricht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 30 years Body Mass Index (BMI) between 20 and 25 kg/m2 Beck Depression Inventory score (BDI; Beck et al. 1961) below 11 Subjects willing and able to give written informed consent and to understand, to participate and to comply with the research project requirements.

Exclusion criteria

Exclusion criteria: Chronic and/or current illness Personal or family history of psychiatric illness Prescription medication use Experience with panic attack/hyperventilation attack Excessive use of alcohol (>1 units per day, 1 unit: 300ml beer, 1 glass of wine or 1 measure of spirit), coffee and/or drugs Smoking Any use of alcohol or drugs during the experiment, starting 2 days before the experimental session until the end of the experiment Pregnancy and breast feeding (also see section 4.3 of research protocol)

Design outcomes

Primary

MeasureTime frame
the main study parameters are changes in mood, state-anxiety, eating behaviour (anticipated preference, appetite, and actual intake and macronutrient selection) and salivary cortisol, both before and after TRP or PLC treatment and before and after stress-induction. Blood samples will be taken twice on the first, and twice on the final day of treatment, to measure dietary (TRP) induced changes in plasma amino acids (TRP/LNAA ratio).

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)