gezonde proefpersonen, fysiologie coagulation thrombosis
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age 18-55 years old written informed consent
Exclusion criteria
Exclusion criteria: use of anticoagulant agents (such as heparin, vitamin K antagonists) use of aspirine, clopidogrel or non steroidal anti-inflammatory drugs within 2 weeks prior to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the peak height of the thrombin generation curve in plasma obtained from non activated platelet rich plasma (PRP) compared with the peak height of the thrombin generation curve in plasma obtained from activated PRP by T different agonists. Thrombin generation will be determined under different assay conditions: triggered with low and hihg TF concentrations in the absence and presence of anti-TFPI antibodies and anti protein S antibodies. In 8 healhty volunteers different available TFPI tests will be performed. | — |
Secondary
| Measure | Time frame |
|---|---|
| TFPI elisa and protein S elisa in plasma obtained from non activated platelet rich plasma (PRP) compared with the peak height of the thrombin generation curve in plasma obtained from activated PRP activated by platelet agnostists. western blot, flow cytometry, activity assays. | — |
Countries
Netherlands
Outcome results
None listed