insulin resistance syndrome Metabolic Syndrome Syndrome X
Conditions
Interventions
Subjects will receive beetroot juice or an isocaloric carbohydrate drink as
control on two separate occasions. The drinks will be provided with two muffins
providing 56.6 g fat.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy overweight and slightly men will be included. Further inclusion criteria are: - Aged between 18 and 70 years - Quetelet-index between 28 and 35 kg/m2 - Mean serum triacylglycerol
Exclusion criteria
Exclusion criteria: - Women - Quetelet-index between 35 kg/m2 - Mean serum triacylglycerol >=1.7 mmol/L - Indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus - Current smoker - Diabetic patients or individuals receiving antidiabetic medication - Familial hypercholesterolemia - Abuse of drugs - More than 21 alcoholic consumptions per week - Unstable body weight (weight gain or loss >3 kg in the past three months) - Use of use of medication known to affect serum lipid metabolism - No severe medical conditions that might interfere with the study. Severe medical conditions are: a high blood pressure, epilepsy, asthma, allergies, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis. - Active cardiovascular disease like congestive heart failure or recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameter is the capacity of vessels to respond to a standardized high-fat meal during the postprandial period as assessed with flow-mediated dilation (FMD) of the brachial artery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study endpoints are the responsiveness of larger arteries to postprandial lipemia measured by pulse wave analysis (PWA) and pulse wave velocity (PWV). Microcirculatory effects will be visualized by retinal imaging. In plasma, metabolic risk markers related to the metabolic syndrome will be investigated: postprandial concentrations of factors related to low-grade inflammation and endothelial activation, and postprandial lipid and glucose metabolism. Finally, effects on blood pressure and heart rate will be studied. | — |
Countries
Netherlands
Outcome results
None listed