hypercholesterolemia / increased serum cholesterol concentration
Conditions
Interventions
During the experimental period, subjects will receive daily 6x250 Amoxicillinum
Gb or placebo for 7 days. Placebo capsules will be filled with gelatine,
cellulosum microcristallinum PH102. Blood sam
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - aged between 18-70 years - mean serum total cholesterol concentrations between 5.0 - 8.0 mmol/L
Exclusion criteria
Exclusion criteria: - mean serum triacylglycerol > 3.0 mmol/L - use of oral anticonceptives (OAC) - pregnant or breastfeeding women - subjects with kidney insufficiencies (defined as creatinine clearance 2 kg in the past 3 months) - known allergy to antibiotics - indication for treatment with cholesterol-lowering drugs according to the Dutch Cholesterol Consensus - use of medication or a medically prescribed diet known to affect lipid or glucose metabolism - active cardiovascular disease like congestive heart failure or recent (
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters are changes in concentrations of HDL cholesterol, triacylglycerol and glucose. Changes in ex vivo and in vitro lipolysis in abdominal subcutaneous adipose and in skeletal tissue will be measured in a subgroup. | — |
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the change in fasting serum LDL-cholesterol concentrations. | — |
Countries
Netherlands
Outcome results
None listed