niet van toepassing N/A
Conditions
Interventions
None listed
Sponsors
Campina
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Subject needs to be in a healthy condition as assessed by health and lifestyle questionnaire, physical examination and results of the pre-study laboratory tests; - Men, aged 30 to 40 years, inclusive, on study day 1; - Body Mass Index (BMI) in the range of 23 to 28 kg/m2; - Waist circumference
Exclusion criteria
Exclusion criteria: - Any clinically significant abnormality as determined by medical history taking and physical examinations obtained during the screening visit that in the opinion of the investigator would interfere with the study objectives or compromise subject safety; - Clinically relevant abnormal laboratory results, ECG, vital signs, or physical findings at screening that in the opinion of the investigator would interfere with the study objectives or compromise subject safety; - A reported food allergy or sensitivity (wheat, milk, eggs, nuts, etc); - Reported unexplained weight loss or weight gain of > 2 kg in the month prior to screening; - Reported slimming or medically prescribed diet;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At the end of each intervention period, t=0 (fasting) and 4 timepoints postprandially, parameters for metabolomics (basal metabolism (energy metabolism, urea cycle, glucose metabolism, ketonbodies, lipid metabolism, aminoacids etc), oxidative stress) and cytokines (IL1-beta, IL-6, IL-8, IL-10, IL-12, TNF-alpha, IFN-gamma) are measured. | — |
Countries
Netherlands
Outcome results
None listed