Technetium-99m HMPAO granulocyte scintigraphy as a tool to measure inflammatory load in Ulcerative Colitis: a cross-sectional study

Technetium-99m HMPAO granulocyte scintigraphy as a tool to measure inflammatory load in Ulcerative Colitis: a cross-sectional study - STATIC: Scintigraphy To Assess The Inflammatory load In ulcerative Colitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37564

Enrollment

Registered

2012-10-22

Start date

2012-11-02

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Diseasehttps://toetsingonline.ccmo.nl/ccmomon.nsf/0/A1A4F7B322EF7BF6C12579EC003742B8?EditDocument Ulcerative Colitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Age from 18 years, either male or female -Established diagnosis (endoscopic/histological proven) of ulcerative colitis with different severities of disease and irrespective of treatment -Clinical Indication for coloscopy for assessment of disease activity -Obtained written informed consent -A completed Truelove Witts Index

Exclusion criteria

Exclusion criteria: -Toxic Megacolon, colon perforation -Infectious disease (Positive stool culture) -Pregnancy -History of Colectomy -Use of i.v. corticosteroids within the last 36 hours -Renal Failure (eGFR

Design outcomes

Primary

Measure	Time frame
The main study parameter is the Summed Scintigraphic Activity Index (SSAI) of WBC scintigraphy (in correlation with endoscopy/histology).	—

Secondary

Measure	Time frame
Secondary parameters are Mayo score by inclusion colonoscopy, biopsies, SCCAI (Simple Clinical Colitis Activity Index), CRP, Albumine and thrombocyte count and fecal calprotectin testing.	—

Countries

Netherlands

Outcome results