allergic esophagitis Idiopathic eosinophilic esophagitis
Conditions
Interventions
Patients will be treated with topical corticosteroids (which are standard
treatment) and will undergo gastroscopy twice.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid-esophageal biopsies before the start of any therapy * Written informed consent * Age 18 * 75 years
Exclusion criteria
Exclusion criteria: * Inability to stop topical corticosteroids * Inability to stop PPI, H2-receptor antagonist or prokinetic drug for 8 weeks * Use of systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the two month period preceding the study * Use of anticoagulants * Use of NSAIDs * History of peptic ulcer disease * History of Barrett*s esophagus * History of GI cancer * History of GI tract surgery (except appendectomy) * ASA class IV or V
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tissue impedance, intercellular spaces, and mucosal permeability to small molecules before and after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Numbers of esophageal intraepithelial eosinophils and mast cells before and after treatment. - Tissue impedance, intercellular spaces and permeability to small molecules and the number of esophageal intraepithelial mast cells and eosinophils before and after 8 weeks of topical corticosteroid therapy are correlated. | — |
Countries
Netherlands
Outcome results
None listed