Cerebrovascular disease stroke
Conditions
Interventions
All subjects will be exposed to a CO2- challenge during an ASL MRI research in
which the CVR and OEF will be measured.
During this research 6 blocks of increased CO2-concentration will be
administe
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the healthy volunteers: - 18 years or older - male or female - informed consent after extensive explanation about the device and the research protocol - healthy;Inclusion criteria for patients: - 18 years or older - male or female - (A)symptomatic extracranial vascular disease (stenosis of 70-100%) or Symptomatic middle cerebral artery occlusion - Informed consent after extensive explanation about the device and the research protocol - healthy
Exclusion criteria
Exclusion criteria: Exclusion criteria for the healthy volunteers: - Contraindications for MRI (claustrophobia, or standard MRI contraindications such as pacemakers or specific metal objects in or around the body) - Previous history of ischemic symptoms - Minors or (legally) incompetent adults;Exclusion criteria for patients: - Contraindications for MRI (claustrophobia, or standard MRI contraindications such as pacemakers or specific metal objects in or around the body) - Unwilling or unable to co-operate with breathing manoeuvres - Known cardiac or pulmonary disease - altered consciousness - Non compliance with prescribed anti-seizure medication - Minors or (legally) incompetent adults
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint in part 1 is to test the feasibility and safety of the CO2-challenge in healthy volunteers. During this part we will also optimize the sequences and the scan protocol. In part 2 of this research the CVR and the OEF in the different patient populations will be compared with the CVR and OEF in the control group. | — |
Countries
Netherlands
Outcome results
None listed