The impact of dietary nitrate ingestion on muscle protein synthesis in elderly type II diabetics

The impact of dietary nitrate ingestion on muscle protein synthesis in elderly type II diabetics - Pro-Nitrate

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37520

Enrollment

Registered

2011-10-28

Start date

2012-01-10

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spiermassametabolisme adult onset diabetes Type 2 diabetes

Interventions

1 bolus ingestion of sodium nitrate (NaNO3-) (0.1 mmol NO3- /kg body weight) or an equalmolar amount of sodium chloride (NaCl) (placebo) dissolved in water and ingested 2.5 h prior to the ingestion

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Male - 65-85 y - Diabetes type II

Exclusion criteria

Exclusion criteria: - Smoking - Insulin use - Obesity (BMI > 30 kg/m2) - Hypertension - All comorbidities interacting with mobility and muscle metabolism - use of anticoagulants and gastric acid inhibitors, blood disease and allergy for lidicaine - blood donation in last 3 months

Design outcomes

Primary

Measure	Time frame
Muscle protein synthetic rate, expressed as fractional synthetic rate (FSR).	—

Secondary

Measure	Time frame
Rate of protein digestion and absorption and whole body protein balance.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)