gum disease periodontitis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) The patient is * 18 years of age; 2) The patient has a hopeless residual dentition of at least 4 teeth for which extraction of all teeth is the only remaining treatment modality. 3) The patient is diagnosed with mild or severe periodontitis (2 approximal sites with at least 2 mm of clinical attachment loss or probing pocket depth of at least 5 mm). 4) The patient is capable of understanding and giving informed consent.
Exclusion criteria
Exclusion criteria: 1) Medical and general contraindications for the surgical procedures; 2) A history of local radiotherapy to the head and neck region; 3) Chemotherapy in the previous 6 months; 4) Systemic or local use of antibiotics in the oral cavity during the last 3 months; 5) Use of anti-septic / antimicrobial therapies (including mouthrinses) in the oral cavity during the last 4 weeks; 6) Patients with dental implants remaining in the oral cavity after full-mouth tooth extraction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the detection frequency of the periodontal pathogens Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis using both culturing and PCR techniques measure prior to full-mouth tooth extraction and at 2 moments after full-mouth tooth extraction (after 4 weeks and 3 months). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Quantitative analysis of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis (culturing and PCR) - Detection frequency of the periodontal pathogens Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum, Parvimonas micra and Campylobacter rectus using culturing. - Total bacterial load (culturing) | — |
Countries
Netherlands
Outcome results
None listed