obesitas and sugar
Conditions
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male sex * Age: 40-70 years * Body fat percentage >25, BMI 27-35 kg/m2 * Diagnosed with type 2 diabetes at least one year before the start of the study * Well-controlled type 2 diabetics: HBA1C
Exclusion criteria
Exclusion criteria: * Unstable body weight (weight gain or loss > 3kg in the last three months) * Total body fat percentage 2 hours total per week * Impaired kidney and/or hepatic function Creatinine 50-100 umol/L;Liver enzymes, within 2 times of normal range of laboratory standard (ASAT 20 grams/day * Participation in another biomedical study within 1 month before the first screening visit * Any contraindication to MRI scanning. These contra-indictations include patients with following devices: o Central nervous system aneurysm clip o Implanted neural stimulator o Implanted cardiac pacemaker of defibrillator o Cochlear implant o Insulin pump o Or metal containing corpora aliena in the eye or brains * Subjects who don*t want to be informed about unexpected medical findings during the screening /study, or do not wish that their physician is informed, cannot participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoints are the differences in whole body- and muscle insulin sensitivity, and mitochondrial fat oxidative capacity after 30 days of resveratrol supplementation compared to the placebo trial. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are the changes in liver and muscle fat storage after 30 days of resveratrol or placebo supplementation. | — |
Countries
Netherlands
Outcome results
None listed