heart failure Left ventricular dyssynchrony
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Informed consent obtained -Chronic heart failure; -New York Heart Association functional class II, III or IV; -QRS duration >=150 ms for NYHA class II or >=120 ms for NYHA class III/IV; -Optimal pharmacological therapy; -Left ventricular ejection fraction
Exclusion criteria
Exclusion criteria: -Contraindications for implantation of a CRT device; -Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are: -99mTc-Tetrofosmin(MPS)-based dyssynchrony and infarct burden measurements -123I-metaiodobenzylguanidine(MIBG)-based Heart-to-Mediastinum(H/M)-ratio and washout measurements -Mismatch in regional distribution between MPS and MIBG The main study parameters will be compared to response to CRT as defined by: A: Reduction in NYHA class and increase in LVEF >= 5% or B: Reduction in LVESV >= 15%. or C: A composite of A + B. | — |
Secondary
| Measure | Time frame |
|---|---|
| in patients with CRT-D implants, MPS/MIBG mismatch will be correlated to adequate discharge of the defibrillator and/or documented ventricular arrhythmia during the follow-up period. | — |
Countries
Netherlands
Outcome results
None listed