Op dit moment wordt het onderzoek bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden in de toekomst mogelijk nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor aandoeningen waarbij een verstoring in de functie van de HPA-as optreedt. Niet van toepassing
Conditions
Interventions
In the experimental group, cortisol levels are elevated exogenously on three
consecutive days by administration of 100 mg hydrocortisone.
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: healthy, female, premenopausal, 18 - 45 years of age
Exclusion criteria
Exclusion criteria: Severe psychiatric and/or somatic diseases, symptoms of infection, use of medication (including oral contraceptives), recent stressful life event
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters of the pilot study are the feasibility of the design (e.g., most useful assessment points for the psychophysiological assessments, safety, drop-out). Variance of endogenous cortisol levels at the evocation phase as well as correlations between cortisol levels at the evocation phase and at baseline in the experimental group will also be assessed, in order to enable a founded power analysis for the main study. In the main study, the main study parameters will be endogenous cortisol levels and psychophysiological parameters (e.g., in response to cognitive and psychosocial tasks) at the evocation phase. | — |
Countries
Netherlands
Outcome results
None listed