hereditary breast cancer mamma carcinoma
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) UV-cohort: patients who are carrier of an unclassified variant. 2) Affected relatives of the UV-cohort patients will be invited for this study. 3) At least one non-affected family member of the UV-cohort patients will be invited to take part in this study. ;The UV-cohort consists of patients diagnosed with a primary breast tumor before the age of 60 years and are unrelated. The patient can be included if only one unclassified variant is found in the BRCA1 or BRCA2 gene. All the participants should be older than 18 years, competent and independent of the researcher. They should all be informed about the study, its goal and its duration. They know about the possibility of interim quitting the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria: - Younger than 18 years old and older than 60 years old. Not affected family members may however, be older than 60 years old. -The participants should be competent to be able to make decision about participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Following the KGCL protocol (Klinisch Genetisch Centrum Leiden), all the affected family members of the patient will be tested on the presence of the Unclassified Variant. Furthermore, also at least one older not affected family member should be tested. This information helps to understand more about the association between carrying a variant and developing cancer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Niet applicable. | — |
Countries
Netherlands
Outcome results
None listed