autonomic function heart function
Conditions
Interventions
None listed
Sponsors
Maxima Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All patients with chronic kidney disease (CKD) stage five who are in a pre-dialysis course and planned for an AVF construction are included in the intervention group.
Exclusion criteria
Exclusion criteria: 1. chronic atrial fibrillation or 2. frequent ventricular premature beats, 3. grade III or IV heart failure (according to the NYHA), 4. with permanent pacemakers, 5. previous vascular access (AVF, graft or venous-catheter) or PD catheter, 6. impaired mental capacity or language barrier.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Autonomic function o The following measurements are made in rest: o heart rate variability (HRV), o blood pressure variability (BPV) and o baroreflex sensitivity (BRS). o Respiratory sinus arrhythmia (RSA) is determined during the deep breathing test. o During the vasalva manoeuvre the following measurements are made: o vasalva ratio (VR) and o blood pressure respons to the vasalva manoeuvre. o Blood pressure and heart rate response to the supine-to-stand-test. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Cardiac function measured using echocardiography - Blood serum levels of several heart markers - Score on the Hand Ischemic Questionnaire (HIQ). - Score on the Minnesota living with heart failure questionnaire (Minnesota). - Successful AVF maturation - Mortality - Morbidity | — |
Countries
Netherlands
Outcome results
None listed