Op dit moment wordt het onderzoek bij gezonde proefpersonen uitgevoerd. In de toekomst zullen de interventies mogelijk toegepast kunnen worden bij de behandeling van een breed scala aan lichamelijke symptomen, waaronder pijn, jeuk en lichamelijke vermoeidheid not applicable
Conditions
Interventions
Expectation effects are induced by means of (1) positive versus neutral verbal
suggestions (that it is effective for 95% versus 5% of people) of the
effectiveness of a substance that is, unknown to
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age >= 18 years fluent in Dutch language
Exclusion criteria
Exclusion criteria: 1) Severe physical or psychological morbidity (e.g., heart and lung diseases, or DSM-IV psychiatric disorders) that would adversely affect participation 2) Chronic pain, itch, or fatigue complaints at present or in the past 3) Use of beta-blockers or other medication that influence heart rate, use of pacemaker 4) Inadequate health for physical exercise as indicated by 1 or more positive responses on the PAR-Q (Physical Activity Readiness Questionnaire) 5) Participants are required not to consume coffee, tea or cola within a 2 hour period prior to the experiment. Nor should they have smoked in the last two hours or consumed alcohol or other drugs in the last 24 hours. Additionally they are required to refrain from heavy physical exercise 24 hours prior to the experimental session
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of this study is the effectiveness of the expectation manipulations in affecting sensitivity to pain, itch, and fatigue, i.e. the difference between the conditions in sensitivity to pain, itch, and fatigue after the expectation manipulations, as rated on Visual Analogue Scales (VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints of this study are to explore the effects of the expectation manipulations on autonomic (heart rate, alpha amylase) and endocrine responses (cortisol), as well as to explore the influence of individual characteristics (e.g., general expectations) on the effectiveness of the expectation manipulations. | — |
Countries
Netherlands
Outcome results
None listed