Does reducing pulmonary hyperciculation affect pulmonary capillary permeability in severe ARDS patients? - a pilot study.

Does reducing pulmonary hyperciculation affect pulmonary capillary permeability in severe ARDS patients? - a pilot study. - RELUF

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37462

Enrollment

Registered

2012-10-03

Start date

2012-10-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute respiratory distress syndrome severe pulmonary disease

Interventions

Titrating cardiac index to 2,5 -3,5 l/min.m2 with a minimal SvO2 of 65%.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: severe ARDS with a PaO2/FiO2 ratio

Exclusion criteria

Exclusion criteria: patients having increased intracranial pressure patients on inotropic support Cardiac index >4 l/min.m2 history of bronchial hyper reactivity Patients with a preterminal illness (active hematologic disease, metastatic malignancy*s) Patients below 18 years or older than 85 years

Design outcomes

Primary

Measure	Time frame
pulmonary leak index	—

Secondary

Measure	Time frame
The titrating cardiac index to 2,5 to 3,5 l/min.m2 with a minimal SvO2 of 65% on ventilator free days, use of rescue therapies and extravascular lung water index, development of organ failure (SOFA), development of the lung injury score.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)