critical limb ischemia severe peripheral vascular disease
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Critical limb ischemia > 2 weeks ankle-brachial pressure index 60 ml/min Written informed consent
Exclusion criteria
Exclusion criteria: Inability to give informed consent Contraindications for MRI, i.e. metal implants or claustrophobia Contraindications for CTA, i.e. allergic reactions to iodinated contrast agents, hyperthyroidism, goiter or pregnancy Patient participates in another study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the burden for the patient of CTA and MRA expressed as the score of the visual analogue scale (VAS) and on a 5-point Likert scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| The diagnostic accuracy of CTA and MRA to identify arterial stenoses > 50% and occlusions in patients with CLI will be compared to DSA as the reference standard. Interobserver agreement for grading arterial stenosis and occlusions with CTA and MRA in patients with CLI will be expressed as weighted *-values. The correlation between arterial calcifications and the diagnostic accuracy of CTA and MRA to identify arterial stenosis and occlusion in patients with CLI will be evaluated. | — |
Countries
Netherlands
Outcome results
None listed