Effects of acute exercise on acetylcarnitine concentration in endurance trained- and untrained subjects

Effects of acute exercise on acetylcarnitine concentration in endurance trained- and untrained subjects - Acetylcarnitine in exercise

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37450

Enrollment

Registered

2012-01-18

Start date

2012-04-27

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inactivity Insulin resistance

Interventions

N.A.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age 18-40 years - Normal weight (BMI 18-25 kg/m2) - Healthy - Stable dietary habits - No use of medication - VO2-max for trained subjects above 50 mL/min/kg - VO2-max for untrained subjects below 40 mL/min/kg

Exclusion criteria

Exclusion criteria: - Any medical condition requiring treatment and/or medication use OR diminishing exercise tolerance - Alcohol consumption of more than 20 g per day (± 2 units) - Unstable body weight (weight gain or loss > 3 kg in the past three months) - Participation in another biomedical study within 1 month prior to the screening visit - Contraindications for MRI scan * Central nervous system aneurysm clips * Implanted neural stimulator * Implanted cardiac pacemaker of defibrillator * Cochlear implant * Iron- containing corpora aliena in the eye or brain * Hearing aids and artificial (heart) valves which is contraindicated for MRS

Design outcomes

Primary

Measure	Time frame
Exercise-induced changes in acetylcarnitine concentrations and dynamics of acetylcarnitine restoration after exercise	—

Secondary

Measure	Time frame
* Substrate oxidation * Blood plasma levels of FFA, triglycerides, glucose and catecholamines	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)