The influence of a genetic difference in the bradykinin B1 receptor gene on the inflammatory response of bradykinin B1 receptor stimulation in human mononuclear cells.

The influence of a genetic difference in the bradykinin B1 receptor gene on the inflammatory response of bradykinin B1 receptor stimulation in human mononuclear cells. - Genetic influence on bradykinin B1 receptor stimulation.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37396

Enrollment

Registered

2012-05-02

Start date

2012-03-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart disease Heart and Vascular disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy persons within the age group of 18-60 years.

Exclusion criteria

Exclusion criteria: Use of ACE inhibitors, AT1 receptor blocker or renin inhibitor.

Design outcomes

Primary

Measure	Time frame
Change in gene-expression of inflammatory genes in response to bradykinin B1 receptor stimulation in human mononuclear cells in the presence or absence of the rs12050217 minor allele.	—

Secondary

Measure	Time frame
Secondary study parameters are to test if the inflammatory response is influenced by stimulation or inhibition of other components of the RAS or kinin system and evaluation of the plasma for the presence of inflammatory cytokines and RAS hormones. In addition, genetic analysis of other SNP*s in the RAS and kinin system in relation to the inflammatory response is also a secondary measurement.	—

Countries

Netherlands

Outcome results