The effect of autonomic nervous system activity on the development of systemic immunosuppression and nosocomial infection in critically ill patients with brain injury

The effect of autonomic nervous system activity on the development of systemic immunosuppression and nosocomial infection in critically ill patients with brain injury - Brain injury-mediated immunosuppression

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37393

Enrollment

150

Registered

2012-07-04

Start date

2013-03-18

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infection contracted in the hospital nosocomial infection

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with ischemic or hemorrhagic cerebrovascular accident or patients with traumatic brain injury, requiring admission and monitoring on the Intensive Care Unti or Central Medium Care

Exclusion criteria

Exclusion criteria: Moribund patients Patients requiring an emergency thoracotomy Known pregnancy; Burns or inhalation injury; Patients who received cardiopulmonary resuscitation with chest compressions (> 5 consecutive minutes) before ICU/CMC arrival Patients with known do-not-resuscitate order prior to inclusion Patients receiving immunosuppressive medication Patients enrolled in a concurrent ongoing interventional, randomized clinical trial

Design outcomes

Primary

Measure	Time frame
nosocomial infection	—

Secondary

Measure	Time frame
heart rate variability, markers of sympathetic, inflammatory and coagulation response, 28- and 60-day mortality, ventilator-free days, length of ICU/CMC stay and hospital stay.	—

Countries

Netherlands

Outcome results