The pathogenesis of dengue virus infection in patients with sickle cell disease

The pathogenesis of dengue virus infection in patients with sickle cell disease - Dengue virus infection and sickle cell disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37382

Enrollment

Registered

2012-03-20

Start date

2012-05-24

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

break-bone fever dengue

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult patient with sickle cell disease (HbSS genotype)

Exclusion criteria

Exclusion criteria: Blood transfusion in the preceding three months. Painful vaso-occlusive crisis/acute chest syndrome/stroke or other acute complications in the preceding 2 weeks. Current use of hydroxyurea.

Design outcomes

Primary

Measure	Time frame
From the supernatant of the HUVECs which were incubated with the DENV infected PBMCs we would like to investigate the following parameters: Virus titre Inflammatory markers (TNF-a, IL-1β) Coagulation markers(TF, sTM)	—

Secondary

Measure	Time frame
-	—

Countries

Netherlands

Outcome results