Monocytes driven VEGF-C mediated water-free storage of salt in healthy male subjects - pilot study

Monocytes driven VEGF-C mediated water-free storage of salt in healthy male subjects - pilot study - SALT on the MOVE

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON37372

Enrollment

Registered

2012-06-28

Start date

2012-12-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hoge bloeddruk, zoutsensitiviteit hypertension sodiumsensitivity

Interventions

The subjects will be randomized in two sequences: first low sodium diet (50 mmol/24 uur) and afterwards high sodium diet (200 mmol/24 uur) with 4 weeks in between, or the other way around. On day 3

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: healthy non-smoking male subjects, age: 18-45 years old

Exclusion criteria

Exclusion criteria: - BMI >= 30 - Diabetes mellitus - Participants with renal diseases - Participants with cardiovascular diseases - Any form of medication - Blood pressure: systolic > 140, diastolic > 90 mmHg - Smoking tobacco - Any surgical or medical condition that in the opinion of the investigator would jeopardize the evaluation of efficacy or safety - History of noncompliance to medical and dietary regimens and participants who are considered potentially unreliable

Design outcomes

Primary

Measure	Time frame
The main primary endpoint of this study is VEGF-c expression in monocytes after low and high sodium diet.	—

Secondary

Measure	Time frame
- Secondary endpoint will be blood pressure response (office blood pressure and 24 hour blood pressure) after low and high sodium diet in healthy male subjects. - Secondary endpoint will be degree of arterial stiffness (by measuring PWV and PWA) after low and high sodium diet in healthy male subjects. - Secondary endpoint will be the relation between VEGF-C expression in monocytes, plasma VEGF-C levels, VEGF-R3 and VEGF-R2, eNOS and RAAS-parameters.	—

Measure

Time frame

- Secondary endpoint will be blood pressure response (office blood pressure and 24 hour blood pressure) after low and high sodium diet in healthy male subjects. - Secondary endpoint will be degree of arterial stiffness (by measuring PWV and PWA) after low and high sodium diet in healthy male subjects. - Secondary endpoint will be the relation between VEGF-C expression in monocytes, plasma VEGF-C levels, VEGF-R3 and VEGF-R2, eNOS and RAAS-parameters.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)