brown adipose tissue thyroid carcinoma
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male or postmenopausal females undergoing a total thyroidectomy for well-differentiated thyroid carcinoma - Age 18-65 years - Stable physical activity levels for at least six months - Note: In case of use of anticoagulation, the dose will be adjusted according to plasma thyroid hormone values.
Exclusion criteria
Exclusion criteria: - Psychological unstable subjects (as judged by the treating medical specialist) - Subjects with mental retardation (as judged by the treating medical specialist) - Subjects with severe behavior disorders (as judged by the treating medical specialist) - Pregnant subjects - The use of the following medication is an exclusion criterium; o ß-blockers - Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study - Abuse of drugs and/or alcohol - Severe diabetes which requires application of insulin or patients with diabetes-related complications - Patients that have donated blood in the past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint of this study is the effect of thyroid hormone and thyroid-stimulating hormone on BAT activity in kBq and SUV. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the effects of thyroid hormone and thyroid-stimulating hormone on energy metabolism, body composotion, plasma values of thyroid hormone, body core temperature, skin surface temperature and skin perfusion. | — |
Countries
Netherlands
Outcome results
None listed