hip surgery hyperglycemia
Conditions
Interventions
The participants will be randomized to one of the two treatment groups, the
liraglutide group (LG) or the control group (CG). Subjects in the LG will start
one day prior to surgery with administrati
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Signed informed consent -Planned for elective hip replacement surgery at the AMC -Age 18-75 years inclusive -Fraxiparine used as anticoagulant drug
Exclusion criteria
Exclusion criteria: - Known type 1 or type 2 diabetes mellitus - Oral corticosteroid use - Use of a Vitamin K antagonist (VKA) as anticoagulant drug - Revision hip replacement - Known coagulation disorders - Peripheral nerve block peri-operative - Known active cancer of the subject - History of chronic pancreatitis or idiopathic acute pancreatitis - Impaired liver function, defined as alanine aminotransferase (ALAT) * 2.5 times upper normal limit - Impaired renal function defined as serum-creatinine * 133 µmol/L for males and * 115 µmol/L for females - Females of child bearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods (adequate contraceptive measures as required by local law or practice) - Known or suspected allergy to trial product(s) or related products - Any condition that the local investigator feels would interfere with trial participation or the evaluation of results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter will be the difference in mean glucose between both groups at day 3 after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study outcomes will be mean differences in coagulation parameters (PAI-1, PAP, F1+2, FVIII, TAT, ETP, PT, APTT, vWF, D-Dimer and antithrombin levels), cortisol and glucagon levels and the difference in proportion of patients who have glucose values in fasting state below 7.8 mmol/l at day 3 after surgery. | — |
Countries
Netherlands
Outcome results
None listed