Hypoperfusion and activated protein C after out of hospital cardiac arrest: triggers for hyperfibrinolysis

Hypoperfusion and activated protein C after out of hospital cardiac arrest: triggers for hyperfibrinolysis - LYSIS-OHCA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37362

Enrollment

Registered

2012-08-14

Start date

2012-09-05

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac arrest cardiopulmonary arrest

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult patients Admitted to shock room by paramedic ambulance (presence of registration files for cardiopulmonary resuscitation) Return of spontaneous circulation (ROSC) after out of hospital cardiac arrest Presence of hyperfibrinolysis

Exclusion criteria

Exclusion criteria: Patients with hemostatic deficiencies or previous hemostatic problems Deceased patients upon ED arrival Absence of a peripheral intravenous catheter Patients using vitamine K antagonists, clopidogrel or dabigatran

Design outcomes

Primary

Measure	Time frame
Main study parameter/endpoint: Hypoperfusion as reflected by cerebral tissue hemoglobin oxygenation and the incidence and onset time of hyperfibrinolysis in OHCA patients	—

Secondary

Measure	Time frame
Secondary study parameters/endpoints - Blood coagulation and fibrinolytic parameters. - Patient demographics including age, gender, body mass index, smoking. - Cause of out of hospital cardiac arrest. - Medication use - Time to cardiopulmonary resuscitation, duration of cardiopulmonary resuscitation, body temperature upon arrival. - Lowest temperature during post-resuscitation cooling, duration of cooling. - Mortality.	—

Measure

Time frame

Secondary study parameters/endpoints - Blood coagulation and fibrinolytic parameters. - Patient demographics including age, gender, body mass index, smoking. - Cause of out of hospital cardiac arrest. - Medication use - Time to cardiopulmonary resuscitation, duration of cardiopulmonary resuscitation, body temperature upon arrival. - Lowest temperature during post-resuscitation cooling, duration of cooling. - Mortality.

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Countries

Netherlands

Outcome results