breast cancer
Conditions
Interventions
None listed
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Women of age * 18 years. * Histologically/cytologically confirmed adenocarcinoma of the breast followed by intended curative surgery and if indicated, also radiotherapy and chemotherapy. * ER + and/or PgR + receptor status. * Indication for treatment with tamoxifen or anastrozole according to the Dutch guidelines. * Disease-free, as defined by the absence of somatic disease activity parameters. * Accessible for follow-up for duration of study. * Karnofsky 80-100. * Written informed consent.
Exclusion criteria
Exclusion criteria: * Palliative treatment or inflammatory breast cancer . * Evidence of distant metastasis (M1). * Concomitant or previous malignancies except for adequately treated carcinoma in situ of the uterine cervix or basal squamous cell carcinoma of the skin. * Hormone Replacement Therapy for treatment of menopausal symptoms, not stopped at least 4 weeks prior to inclusion in the study. * Current psychological or psychiatric treatment. * Treatment with anti-depressive drugs, anti-epileptic drugs, benzodiazepines. * Insufficient command of the Dutch language to fill out questionnaires. * Contra-indication for MR examinations (e.g. claustrophobia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological measures that quantify cognitive functioning, and parameters derived from brain imaging methods (MEG and fMRI). | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed