Taste and smell changes in testicular cancer patients treated with cisplatin based chemotherapy

Taste and smell changes in testicular cancer patients treated with cisplatin based chemotherapy - Taste, smell, and chemotherapy (TASTY)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON37350

Enrollment

140

Registered

2012-04-12

Start date

2012-07-10

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

smaak- en geurfunctie taste and smell

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Cancer patients: - Testicular cancer patients treated with cisplatin based chemotherapy - Age range 18-50 - Ability to comprehend Dutch (both reading and writing) - Signed informed consent;Healthy controls: - Healthy males - Age 18-50 years - Ability to comprehend Dutch (both reading and writing) - Signed informed consent

Exclusion criteria

Exclusion criteria: Cancer patients - Mental disability -Smoking (cross-sectional part);Healthy controls: - Mental disability - Ever diagnosed with cancer - History of taste and smell abnormalities - Smoking (cross-sectional part)

Design outcomes

Primary

Measure	Time frame
Scores of gustatory and olfactory function of patients with disseminated testicular cancer treated with cisplatin based chemotherapy will be investigated using physiological tests (taste strips and Sniffin Sticks*) and using a questionnaire on taste and smell function to investigate the subjective perception of taste and smell function among these patients. During the chemotherapeutic treatment the measurements will be re-assessed several times to investigate possible changes in gustatory and olfactory function before, during and after chemotherapy. Measurements will also be carried out 1, 3, 5 and 7 years after chemotherapy to investigate possible changes in gustatory and olfactory function in the long-term.	—

Measure

Time frame

Scores of gustatory and olfactory function of patients with disseminated testicular cancer treated with cisplatin based chemotherapy will be investigated using physiological tests (taste strips and *Sniffin* Sticks*) and using a questionnaire on taste and smell function to investigate the subjective perception of taste and smell function among these patients. During the chemotherapeutic treatment the measurements will be re-assessed several times to investigate possible changes in gustatory and olfactory function before, during and after chemotherapy. Measurements will also be carried out 1, 3, 5 and 7 years after chemotherapy to investigate possible changes in gustatory and olfactory function in the long-term.

—

Secondary

Measure	Time frame
The secondary parameters are food preference, dietary intake, quality of life, BMI, body composition (bone and fat mass), audiograms, BRS, blood glucose level and DNA. We will focus on changes in these parameters due to changes in gustatory and olfactory function as a consequence of chemotherapy.	—

Countries

Netherlands

Outcome results